MISIT - Minimally Invasive Surgery and Interventional Techniques


			Minimally Invasive Surgery and Interventional Techniques

			Department of Biomechanical Engineering - Delft University of Technology

Dr.ir. Nick van de Berg
Researcher		Delft University of Technology
		BioMechanical Engineering

	(+31)-15-2782054	Mekelweg 2
	n.j.vandeberg@tudelft.nl	2628 CD, Delft
	www.misit.nl	Room F-0-200

Bio | Projects | Assignments

Biography

I’m passionate about early-stage translational research (bench-to-bedside), with a focus on personalized care in oncology, involving R&D of medical devices (hardware) and image-guidance (software). Current projects include:

Architect: personalized 3D printed brachytherapy applicators (based on MR images) for an optimal dose to the tumour and minimal dose to surrounding healthy tissues.
HSI-GO: treatment plan personalization by AI-based recognition of ovarian and vulvar tumours, using hyperspectral imaging.
Steerable needles: actively adaptable needles for prostate and gynaecological brachytherapy.
Back on the bike: Living Lab for patients to find personalized solutions for bicycling re-enablement, aiming to mitigate (cancer-related) perineal pain while cycling.

Personal pages: Erasmus MC - Research Gate - Google Scholar - Linkedin - GitHub (MISIT)

Education & employment

2020 - present: staff researcher, Erasmus MC, Department of Gynaecological Oncology.
2018 - 2020: post-doc researcher, Erasmus MC, Department of Radiology & Nuclear Medicine.
2017: Visiting Researcher, SINTEF - Department of Medical Technology, Norway.
2016 - present: post-doc researcher, Delft University of Technology, Department of Biomechanical Engineering.
2015: Visiting Researcher, ACMIT - Austrian Center for Medical Innovation and Technology, Austria.
2012 - 2016: PhD candidate, Delft University of Technology, 3mE, Department of Biomechanical Engineering. Thesis: Needle Steering Mechanics and Design Cases (oct 25, 2016), promotors Dr. John J. van den Dobbelsteen and Prof. dr. Jenny Dankelman.
2010: Intern Leiden University Medical Center (LUMC) + KU Leuven, Department of Obstetrics.
2008 - 2011: M.Sc. Biomedical Engineering, thesis: Soft tissue dissection with an ultrasonic snare and the quantification of thermal spread, advisor Dr. John van den Dobbelsteen

Publications

de Vries M*, Wijntjes M*, Sikorski J, Moreira P, van de Berg NJ, van den Dobbelsteen JJ, Misra S (*equal contributions), "MR-guided HDR prostate brachytherapy with teleoperated steerable needle", J Robot Surg, (Springer), 2023.
van de Berg NJ, Nieuwenhuyzen-de Boer GM, Gao XS, Rijstenberg LL, van Beekhuizen HJ, "Plasma Device Functions and Tissue Effects in the Female Pelvis—A Systematic Review", Cancers, 15(8), 2386 (MDPI), 2023.
van de Berg NJ*, van Beurden FP*, Wendel-Vos WGC, Duijvestijn M, van Beekhuizen HJ, Maliepaard M, van Doorn HC (*equal contributions), "Patient-reported mobility, physical activity, and bicycle use after vulvar carcinoma surgery", Cancers, 15(8), 2324 (MDPI), 2023.
Nieuwenhuyzen-de Boer GM, van de Berg NJ, Gao XS, Ewing-Graham PC, van Beekhuizen HJ, "The effects of Neutral Argon Plasma versus electrocoagulation on tissue in advanced-stage ovarian cancer: A case series", J Ovarian Res, 15:140, pp. 1-6, 2022 (BMC).
van Vliet-Pérez SM, van de Berg NJ, Manni F, Lai M, Rijstenberg LL, Hendriks BHW, Dankelman J, Ewing‐Graham PC, Nieuwenhuyzen-de Boer GM, van Beekhuizen HJ, "Hyperspectral imaging for tissue classification after advanced stage ovarian cancer surgery - a pilot study", Cancers, 14(6), 1422, pp. 1-12, 2022 (MDPI).
Sánchez-Margallo JA, Tas L, Moelker A, van den Dobbelsteen JJ, Sánchez-Margallo FM, Langø T, van Walsum T, van de Berg NJ, "Block-matching based registration to evaluate ultrasound visibility of percutaneous needles in liver-mimicking phantoms", Med Phys, 48(12), pp. 7602-12, 2021 (Wiley).
Somerwil PC, Nout RA, Mens JWM, Kolkman-Deurloo IKK, van Beekhuizen HJ, Dankelman J, van de Berg NJ, "An anthropomorphic deformable phantom of the vaginal wall and cavity", Biomed Phys Eng Express, 7, 055019, pp. 1-7, 2021 (IOP).
van Doorn HC, Barroso EM, Koljenović S, Ewing-Graham PC, Soares MRN, van de Berg NJ, Bakker-Schut TC, Puppels GJ, "Raman spectroscopy for guidance of vulvar cancer surgery: a pilot study", Biomed Opt Express, 12(5), pp. 3008-20, 2021 (OPTICA).
van de Berg NJ, Meeuwsen FC, Doukas M, Kronreif G, Moelker A, van den Dobbelsteen JJ, "Steerable needles for radio-frequency ablation in cirrhotic livers", Sci Rep, 11:309, 2021 (Nature).
Prinsen D, van Dijke AP, Horeman-Franse T, van de Berg NJ, Loeve AJ, "Lethal smothering with a pillow–How 181 music festival visitors tried to kill a dummy", Forensic Sci Int, 110521, 2020 (Elsevier).
de Lange D, van den Dobbelsteen JJ, Moelker A, van de Berg NJ, "Ultrasound-guided percutaneous liver biopsy: a review on obtaining adequate specimens", J Med Devices, 14(3): 034503, 2020 (ASME).
Laan RC, Nout RA, Dankelman J, van de Berg NJ, "MRI-driven design of customised 3D printed gynaecological brachytherapy applicators with curved needle channels", 3D Print Med, 5(8), pp 1-8, 2019 (Springer).
van de Berg NJ, Sánchez-Margallo JA, van Dijke AP, Langø T, van den Dobbelsteen JJ, "A methodical quantification of needle visibility and echogenicity in ultrasound images", Ultrasound Med Biol, 45(4), pp 998-1009, 2019 (Elsevier).
de Jong TL, van de Berg NJ, Tas L, Dankelman J, van den Dobbelsteen JJ, "Needle placement errors: do we need steerable needles in interventional radiology?", Medical Devices (Auckl), 11:259-265, 2018 (Dovepress).
van de Berg NJ, Sánchez-Margallo JA, Langø T, and van den Dobbelsteen JJ, “Compliant joint echogenicity in ultrasound images: towards highly visible steerable needles”, SPIE Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling, 105760X, pp 1-6, 2018 (SPIE).
van de Berg NJ, de Jong TL, van Gerwen DJ, Dankelman J, and van den Dobbelsteen JJ. "The influence of tip shape on bending force during needle insertion", Sci Rep, 7:40477, pp 1-8, 2017 (Nature).
van de Berg NJ, Dankelman J, and van den Dobbelsteen JJ. "End-point accuracy in manual control of a steerable needle", J Vasc Interv Radiol, 28(2), pp 276-283, 2017 (Elsevier).
Shahriari N, Roesthuis RJ, van de Berg NJ, van den Dobbelsteen JJ, Misra S. "Steering an Actuated-Tip Needle in Biological Tissue: Fusing FBG-Sensor Data and Ultrasound Images", IEEE ICRA 2016 (IEEE Xplore).
Roesthuis RJ, van de Berg NJ, van den Dobbelsteen JJ, and Misra S. "Modeling and steering of a novel actuated-tip needle through a soft-tissue simulant using fiber bragg grating sensors", IEEE ICRA 2015 (IEEE Xplore).
van de Berg NJ, Dankelman J, and van den Dobbelsteen JJ. "Design of an actively controlled steerable needle with tendon actuation and FBG-based shape sensing", Med Eng Phys, 37(6), pp 617-22, 2015 (Elsevier).
van de Berg NJ, van Gerwen DJ, Dankelman J, and van den Dobbelsteen JJ. "Design choices in needle steering - a review", Mechatronics IEEE/ASME T, 20(5), pp 2172-83, 2015 (IEEE Xplore).
van de Berg NJ, van den Dobbelsteen JJ, Jansen FW, Grimbergen CA, and Dankelman J. "Energetic soft-tissue treatment technologies: an overview of procedural fundamentals and safety factors", Surg Endosc, 27(9), pp 3085-99, 2013 (Springer).

Keynote / invited speaker

van de Berg NJ, "Patient-specific applicator for brachytherapy", at M3d+it/Design of Medical Devices Europe (invited), Vienna, Dec 2019.
van de Berg NJ, "Steerable needles and 3D printing of medical devices", at Society for Medical Innovation and Technology (invited), Heilbronn, Germany, Oct 2019.
van de Berg NJ, "Data-driven design of steerable needles", at Fibre Optic Shape and Deformation Sensing: An Emerging Technology IOP (keynote), London, United Kingdom, May 2019.

Refereed conference contributions

Paiman P, van Beekhuizen HJ, van de Berg NJ, "Advancing In-vivo Vulvar Tumour Detection: Combining AI and Hyperspectral Imaging", BNAIC/BENELEARN, Delft, 2023.
van de Weerd LS, van de Laar RLO, Roes EM, van Doorn HC, Dankelman J, Rijstenberg LL, van de Berg NJ, Nieuwenhuyzen-de Boer GM, van Beekhuizen HJ, "Hyperspectral imaging for the in-vivo detection of ovarian cancer", Int Gyn Cancer Society (IGCS), Seoul, 2023.
Straathof R, van Vliet-Pérez SM, Kolkman-Deurloo IKK, Nout RA, Heijmen BJM, Wauben LSGL, Dankelman J, van de Berg NJ, "Fast catheter trajectory planning for patient-tailored cervical cancer brachytherapy applicators", Eur Society for Radiotherapy and Oncology (ESTRO), Vienna, 2023.
van Vliet–Pérez SM, Crone TP, van den Broek RB, Straathof R, Wauben LSGL, van de Berg NJ, Dankelman J, Heijmen BJM, Kolkman-Deurloo IKK, Nout RA, "Quantitative analysis of vaginal and uterine geometry for patient-tailored BT applicator development", Eur Society for Radiotherapy and Oncology (ESTRO), Vienna, 2023.
van de Berg NJ, van Beurden FP, van Beekhuizen HJ, Maliepaard M, van Doorn HC, "Patient-reported bicycle use and mobility of vulvar cancer patients", Biomedical Engineering Conference (BME), Edgmond aan Zee, The Netherlands, 2023.
van Beurden FP, van de Berg NJ, van Beekhuizen HJ, Maliepaard M, van Doorn HC, "Patient-reported mobility and bicycle use after vulvar cancer surgery", Eur Society of Gynaecological Oncology (ESGO), Berlin, Germany, 2022.
de Wilde K, Roolvink TW, Scholten MP, Plat RW, van de Berg NJ, van Doorn HC, "A comparison of methods to measure surface area of vulvar tumors", Eur Society of Gynaecological Oncology (ESGO), Berlin, Germany, 2022.
Straathof R, Meijaard JP, van Vliet-Pérez S, Kolkman-Deurloo IKK, Nout RA, Heijmen BJM, Wauben LSGL, Dankelman J, van de Berg NJ, "Multibody dynamic modelling of the behaviour of flexible cervical cancer brachytherapy instruments", E22-1262, Eur Society for Radiotherapy and Oncology (ESTRO), Copenhagen, Denmark, 2022.
van Vliet–Pérez SM, van Paassen R, Wauben LSGL, Straathof R, van de Berg NJ, Dankelman J, Heijmen BJM, Kolkman-Deurloo IKK, Nout RA, "Patient experience and time-action analysis during cervical cancer brachytherapy", E22-1863, Eur Society for Radiotherapy and Oncology (ESTRO), Copenhagen, Denmark, 2022.
van Vliet-Pérez SM, van de Berg NJ, Manni F, Lai M, Rijstenberg L, Hendriks B, Dankelman J, Ewing-Graham PC, Nieuwenhuyzen-de Boer G, van Beekhuizen HJ, "Hyperspectral imaging for tissue classification after advanced stage ovarian cancer surgery - a pilot study", Eur Society of Gynaecological Oncology (ESGO), Prague, Czech, 2021.
Nieuwenhuyzen-de Boer G, van de Berg NJ, Gao XS, Ewing-Graham PC, van Beekhuizen HJ, "PlasmaJet gives less tissue damage than electrocoagulation device during cytoreductive surgery for advanced-stage ovarian cancer", Eur Society of Gynaecological Oncology (ESGO), Prague, Czech, 2021.
van de Berg NJ and van den Dobbelsteen JJ, "Ultrasound Image Analysis to Quantify Needle Visibility and Echogenicity", Biomedical Engineering Conference (BME), Edgmond aan Zee, The Netherlands, 2019.
van de Berg NJ, Sánchez-Margallo JA, Langø T, and van den Dobbelsteen JJ, “Compliant joint echogenicity in ultrasound images: towards highly visible steerable needles”, SPIE Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling, Houston, USA, 2018 (SPIE).
van de Berg NJ, Laan RC, Nout RA, "Custom-fit 3-D printed needle applicators for gynaecological brachytherapy", Design of Medical Devices Europe (DMD Eur), Eindhoven, The Netherlands, 2017.
van de Berg NJ, Laan RC, Nout RA, "Additive manufacturing for gynaecological brachytherapy: custom-fit applicators based on MRI data", Society for Medical Innovation and Technology (iSMIT), Turin, Italy, 2017.
van de Berg NJ, Dankelman J, and van den Dobbelsteen JJ. "Evaluation of manual needle steering under image guidance", Biomedical Engineering Conference (BME), Edgmond aan Zee, The Netherlands, 2017.
[Technical Exhibition] de Jong TL, van de Berg NJ, Tas L, van den Dobbelsteen JJ, "Steerable needles in radiologic liver interventions", Questionnaire & Exhibition at CIRSE conference, Barcelona, Spain, 2016.
van de Berg NJ, van den Dobbelsteen JJ. "Manual control of a tip articulated needle", Joint conference: Society for Medical Innovation and Technology & Design of Medical Devices Europe (iSMIT / DMD Eur), Delft, The Netherlands, 2016.
Shahriari N, Roesthuis RJ, van de Berg NJ, van den Dobbelsteen JJ, Misra S. "Steering an Actuated-Tip Needle in Biological Tissue: Fusing FBG-Sensor Data and Ultrasound Images", IEEE ICRA, Stockholm, Sweden, 2016 (IEEE Xplore).
van de Berg NJ, van den Dobbelsteen JJ. "Shared-control system for inserting a tip-steered needle", Society for Medical Innovation and Technology (iSMIT), Brno, Czech Republic, 2015.
van de Berg NJ, van den Dobbelsteen JJ. "A hand-held actively steered needle for percutaneous interventions", Design of Medical Devices Europe (DMD Eur), Wiener Neustadt, Austria, 2015.
van de Berg NJ, Roesthuis RJ, Misra S, and van den Dobbelsteen JJ. "Haptic shared control of a teleoperated steerable needle", World Haptics, Chicago, USA, 2015.
Roesthuis RJ, van de Berg NJ, van den Dobbelsteen JJ, and Misra S. "Modeling and steering of a novel actuated-tip needle through a soft-tissue simulant using fiber bragg grating sensors", IEEE ICRA, Seattle, USA, 2015 (IEEE Xplore).
van de Berg NJ, Dankelman J, and van den Dobbelsteen JJ. "Active needle steering with visual and haptic feedback", Biomedical Engineering Conference (BME), Edgmond aan Zee, The Netherlands, 2015.
van de Berg NJ, and van den Dobbelsteen JJ. "Tip-Steered Needle", DEMO in collaboration with Arkenbout EAA, "Using Kinect with 3Gear Systems software to control a tip-steered needle". Design of Medical Devices Europe (DMD Eur), Delft, The Netherlands, 2014.
van de Berg NJ, and van den Dobbelsteen JJ. "Closed loop control of an actively steered needle with FBG-based shape feedback", Society for Medical Innovation and Technology (iSMIT), Shanghai, China, 2014.
van de Berg NJ, and van den Dobbelsteen JJ. "Robot-assisted needle steering by a cable driven tip actuator", Design of Medical Devices Europe (DMD Eur), Delft, The Netherlands, 2013.
van de Berg NJ, and van den Dobbelsteen JJ. "Validation of a new tip actuated needle steering system", Society for Medical Innovation and Technology (iSMIT), Baden Baden, Germany, 2013.
van de Berg NJ, and van den Dobbelsteen JJ. "The design of a robotic actuator for flexible needle steering", Biomedical Engineering Conference (BME), Edgmond aan Zee, The Netherlands, 2013.
Gahler MC, van de Berg NJ, Rhemrev J, Jansen FW, and van den Dobbelsteen JJ. "Vaginal Approach for Uterus Separation During Laparoscopic Hysterectomy", Design of Medical Devices (DMD), Minneapolis, USA, 2010

Abstract in Journal of Medical Devices, 2010 4(2) - Conference Abstracts 027514 (ASME).

Arkenbout EA, van de Berg NJ, Visser RJ, Schutte S, van der Helm, FCT, van den Bosch WA, and Simonsz HJ. "Eyelid pressure measurements for early diagnosis", The Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA, 2008

Abstract in Invest Ophthalmol Vis Sci, ARVO 2008 - E-Abstract 5265-A535 (IOVS).

Patents

van de Berg NJ, van den Dobbelsteen JJ, "Needle structure comprising a hollow cannula and a stylet", WO/2020/139083, 02.07.2020.

Teaching activities

2017 - 2019: KT1000WI MATLAB exam design (with Dr. Ir. Arjo Loeve).
2014 - 2018: BM41050 & BM1106 Applied Experimental Methods: Medical Instruments.
2013: WB1630 Statics seminars.
2013: WBP202 Haptic Experimental Design.
Graduate student supervision (S) and committee memberships (CM):

Remco Dirks (S): TU Delft, expected 2023,
Ana Alonso Freitas (S): TU Delft, expected 2023,
Ir. Haitao Jiang (S): TU Delft + TU Munich, expected 2023,
Ir. Lotte Pool (S): TU Delft, 2023,
Ir. Defne Ünal (S): TU Delft, 2023,
Ir. Parsa Paiman (S): TU Delft, 2023,
Ir. Frank van Beurden (S): TU Delft, 2023,